![]() Severe Cutaneous Adverse Reactions: Discontinue at the first signs or symptoms of severe cutaneous adverse reactions or other signs of hypersensitivity and consider further evaluation.Bone Fracture: Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine.Clostridium difficile-Associated Diarrhea: PPI therapy may be associated with increased risk.Acute Tubulointerstitial Nephritis: Discontinue treatment and evaluate patients.Consider additional follow-up and diagnostic testing. Gastric Malignancy: In adults, symptomatic response does not preclude the presence of gastric malignancy.Starting dose is 60 mg once daily (varies with individual patient, see full prescribing information) as long as clinically indicated ( 2.1) Maintenance of Healing of EE due to Acid-Mediated GERDĢ0 mg once daily ( 2.1)**** See full prescribing information for weight based dosing in pediatric patients 1 year of age and older ( 2.2) pylori Eradication to Reduce the Risk of Duodenal Ulcer RecurrenceĮach drug twice daily for 10 days ( 2.1)*Ĥ0 mg once daily for 14 days** 500 mg three times daily for 14 days ( 2.1)Ģ0 mg once daily for up to 4 weeks (2.1) See full prescribing information for weight based dosing in pediatric patients 1 year of age and older ( 2.2)Ģ0 mg once daily for 4 to 8 weeks ( 2.1)*** See full prescribing information for weight based dosing in pediatric patients 1 month of age and older ( 2.2) Recommended Adult ( 2.1) and Pediatric Dosage ( 2.2)Ģ0 mg once daily for 4 weeks some patients may require an additional 4 weeks ( 2.1) Reduce the dosage to 10 mg once daily for patients with hepatic impairment (Child-Pugh Class A, B, or C) and Asian patients ( 8.6, 8.7). *** an additional 4 weeks of treatment may be given if no response if recurrence additional 4 to 8 week courses may be considered. ** if ulcer present, continue omeprazole 20 mg once daily for an additional 14 days. * if ulcer present, continue omeprazole 20 mg once daily for an additional 18 days.
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